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Academy Award-winning filmmaker Alex Gibney and New York Times best-selling author Michael Pollan present this documentary series event in four parts, each focused on a different mind-altering substance: LSD, psilocybin, MDMA, and mescaline. With Pollan as our guide, we journey to the frontiers of the new psychedelic renaissance – and look back at almost-forgotten historical context – to explore the potential of these substances to heal and change minds as well as culture. How to Change Your Mind is directed by Emmy-nominated filmmaker Alison Ellwood and two-time Academy Award-nominated and Emmy-winning filmmaker Lucy Walker. SUBSCRIBE: http://bit.ly/29qBUt7 About Netflix: Netflix is the world's leading streaming entertainment service with 222 million paid memberships in over 190 countries enjoying TV series, documentaries, feature films and mobile games across a wide variety of genres and languages. Members can watch as much as they want, anytime, anywhere, on any internet-connected screen. Members can play, pause and resume watching, all without commercials or commitments. How to Change Your Mind | Official Trailer | Netflix https://youtube.com/Netflix Author Michael Pollan leads the way in this docuseries exploring the history and uses of psychedelics, including LSD, psilocybin, MDMA and mescaline.

Quando tantos estão lutando por conexão, inspiração e esperança, Fantastic Fungi nos reúne como criadores interconectados de nosso mundo. Fantastic Fungi, dirigido por Louie Schwartzberg, é um filme de mudança de consciência que nos leva a uma viagem imersiva no tempo e na escala da terra mágica sob nossos pés, uma rede subterrânea que pode curar e salvar nosso planeta. Através dos olhos de renomados cientistas e micologistas como Paul Stamets, autores de best-sellers Michael Pollan, Eugenia Bone, Andrew Weil e outros, nos tornamos cientes da beleza, inteligência e soluções que o reino dos fungos nos oferece em resposta a alguns de nossos desafios médicos, terapêuticos e ambientais.

Paul Stamets is a legendary mycologist, and in this tour de force keynote at NextMed Health (http://NextMed.Health) Paul shares his perspectives on psilocybin mushrooms and psychedelics role in mental health and medicine. More about Paul Stamets: https://www.nextmed.health/bio-paulstamets NextMed Health is a unique cross-disciplinary program exploring the cutting edge of health, medicine, and technology. Join us for our next program, December 10-13th, 2024. Sign up for our NextMed Health Newsletter for more on the future of health and medicine: https://www.nextmed.health/join Follow us on Twitter @NextMedHealth: http://twitter.com/NextMedHealth

For more information visit http://www.scienceandnonduality.com In this entertaining talk from SAND18, James Fadiman, "America's wisest and most respected authority on psychedelics and their use," describes the citizen science of his recent investigations into the effects of microdosing, and shares some fascinating stories from the hundreds he has gathered in his ongoing research. http://www.jamesfadiman.com Science And NonDuality is a community inspired by timeless wisdom, informed by cutting-edge science, and grounded in personal experience. We come together in an openhearted exploration to further our individual and collective evolution. New ways of being emerge. We embody our interconnectedness and celebrate our humanity.

In this episode, I discuss what psilocybin is (chemically) and how it works at the cellular and neural circuit level to trigger neuroplasticity, which is our brain’s ability to rewire itself in ways that lead to long-lasting shifts in our emotional, cognitive and behavioral patterns and abilities. I discuss the emerging clinical trial evidence for the use of psilocybin in the treatment of depression, addictions and other psychiatric challenges. I explain the typical duration and phases of a psilocybin journey, the different categories of dosages often used and I explain the importance of set, setting and support when using psychedelics. I explain which groups of people place themselves at great risk by taking psilocybin as well as groups that could benefit, and I highlight the rapidly changing legal and medical landscape around psilocybin. This episode is a thorough exploration of psilocybin from the scientific and clinical literature perspective and ought to be of interest to anyone curious about psilocybin, mental health, neuroplasticity and/or psychedelics more generally. #HubermanLab #Science Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Eight Sleep: https://eightsleep.com/huberman ROKA: https://roka.com/huberman HVMN: https://hvmn.com code: “Huberman” LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Social & Website Instagram: https://www.instagram.com/hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network Articles The neural basis of psychedelic action: https://go.nature.com/3VInMlE The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers: https://bit.ly/3VW8iL7 Increased low-frequency brain responses to music after psilocybin therapy for depression: https://bit.ly/3LKj6XK Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression: https://bit.ly/42c7y6x Brief structured respiration practices enhance mood and reduce physiological arousal: https://bit.ly/3wEvGRf Therapeutic use of psilocybin: Practical considerations for dosing and administration: https://bit.ly/3HPHLZM Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo: https://bit.ly/3HQ8J3z Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics: https://bit.ly/44Gpwjx Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression: https://bit.ly/3pjvu9N Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: https://bit.ly/3sFSGMM The costs and benefits of psychedelics on cognition and mood: https://bit.ly/3NNyEwI Other Resources The Physiological Sigh: https://youtu.be/rBdhqBGqiMc Dr. Matthew Johnson: Psychedelic Medicine: https://hubermanlab.com/dr-matthew-johnson-psychedelic-medicine Timestamps 00:00:00 Psilocybin, Legal Considerations 00:08:32 Sponsors: Eight Sleep, ROKA, HVMN 00:12:00 Psilocybin Becomes Psilocin in the Gut, Serotonin 00:17:00 The Serotonin 2A Receptor, Therapeutic Outcomes SSRIs vs. Psilocybin 00:21:40 Serotonin Receptor Expression; Visual Hallucinations & Eyes Closed 00:27:21 Safety & Cautions for Specific Patient Populations 00:29:13 Sponsor: AG1 (Athletic Greens) 00:30:28 Psilocybin, “Magic Mushrooms” Dosing, Micro-Dosing, “Heroic Doses” 00:36:21 Psychedelic Journey: Set, Setting & Support 00:43:43 Music & the Psilocybin Journey; Duration of Effects 00:48:58 Psilocybin & the Brain: Subjective Experiences, Perception 00:58:36 Sponsor: LMNT 00:59:48 Brain Networks & Therapeutic Outcomes 01:05:23 Creativity; Music, Emotionality & Psychedelic Journeys 01:12:39 Depression & Psychedelics as Neuroplasticity “Wedge” 01:16:53 Positive Psychedelic Journeys, Unity, “Oceanic Boundlessness” 01:25:23 “Bad Trips”, Anxiety & Physiological Sighs 01:32:57 Therapeutic Use of Psilocybin 01:36:11 Neuroplasticity, Structural Brain Changes & Psilocybin 01:48:08 Psychedelics: Therapeutic Breakthroughs & Depression 01:56:37 Combining Psilocybin Therapy & Talk Therapy, Antidepressant Effects 02:03:11 Psilocybin Experience & Mental Health 02:06:42 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://hubermanlab.com/disclaimer

Dr. Sam Harris explains the utility of psychedelics to Dr. Andrew Huberman. Dr. Sam Harris is the author of multiple best-selling books and is a world-renowned public-facing intellectual on meditation, consciousness, free will, psychedelics and neuroscience. He is also the creator of Waking Up and the host of the Making Sense podcast. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab podcast. Full episode: https://youtu.be/-wIt_WsJGfw Show notes: https://hubermanlab.com/dr-sam-harris-using-meditation-to-focus-view-consciousness-and-expand-your-mind/ #HubermanLab #SamHarris #Psychedlics Social & Website Instagram: https://www.instagram.com/hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network The Huberman Lab podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

In this episode, my guest is Robin Carhart-Harris, PhD, distinguished professor of neurology and psychiatry at the University of California, San Francisco. He is one of leading researchers in the study of how psychedelics such as psilocybin, LSD and DMT can change the human brain and in doing so, be used to successfully treat various mental health challenges such as major depression, anorexia, obsessive-compulsive disorder (OCD) and addiction. He explains how psilocybin induces sustained changes in adaptive brain wiring and cognition. We discuss the key components of safe and effective psychedelic journeys, the role of hallucinations, the use of eye-masks to encourage people to “go internal,” and music, as well as what effective therapist support consists of before, during and after the session (also known as integration). We discuss micodosing vs. macrodosing and how researchers control for placebo effects in psychedelic research. We also discuss the current legal landscape around psychedelic therapies. Psychedelic therapies are fast emerging as powerful and soon-to-be mainstream treatments for medical health disorders, but they are not without their risks. As such, this episode ought to be of use to anyone interested in brain plasticity, mental health, psychology or neuroscience. #HubermanLab #Science Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Eight Sleep: https://eightsleep.com/huberman Levels: https://levels.link/huberman HVMN: https://hvmn.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://www.livemomentous.com/huberman The Brain Body Contract https://hubermanlab.com/tour Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network Dr. Robin Carhart-Harris Academic Profile: https://profiles.ucsf.edu/robin.carhart-harris Publications: https://profiles.ucsf.edu/robin.carhart-harris#toc-id3 Support USCF Psychedelic Research Fund: https://makeagift.ucsf.edu/site/SPageServer?pagename=A1_API_GeneralGivingForm&Other=Psychedelic%20Research%20Fund%20zzz%207031398-SFFDN UCSF Clinical Trials Enrollment: https://clinicaltrials.ucsf.edu/psychedelic-experiences Twitter: https://twitter.com/RCarhartHarris TEDx Talk: https://youtu.be/MZIaTaNR3gk Articles Self-blinding citizen science to explore psychedelic microdosing: https://bit.ly/3IxMrUJ Trial of Psilocybin versus Escitalopram for Depression: https://bit.ly/3Os2I11 Pivotal mental states: https://bit.ly/3ITFVYH Increased global integration in the brain after psilocybin therapy for depression: https://go.nature.com/3q4Sb1z Structure-based discovery of nonhallucinogenic psychedelic analogs: https://bit.ly/41Svyux Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research: https://bit.ly/3Wr1q8C MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study: https://go.nature.com/3WqI2Zd Timestamps 00:00:00 Dr. Robin Carhart-Harris 00:02:12 Sponsors: Eight Sleep, Levels, HVMN 00:05:41 The Brain-Body Contract 00:06:31 Origin of the Word: “Psychedelics”; Pharmacology 00:12:05 Psychedelics & Revealing the Unconscious Mind, Psychotherapy 00:17:32 Microdosing 00:26:08 Psilocybin vs. Magic Mushroom Doses 00:28:28 “Psychedelic-Therapy”, Music 00:35:12 Sponsor: AG1 (Athletic Greens) 00:36:26 Psychedelic Journey: “Trust, Let Go, Be Open” 00:43:01 Negative Emotions, Fear & Psychedelics 00:46:21 Global Functional Connectivity, Serotonin 2A Receptor; Subjective Experiences 00:52:33 Pharmacology: Therapeutics without Psychedelic Effects; SSRIs 00:58:45 Psilocybin & Depression; Long-Term Effects: Connectivity & Neuroplasticity 01:09:14 Sponsor: LMNT 01:10:26 Psilocybin Therapy & Anorexia 01:12:56 Integration Phase & Psychedelic-Therapy; Meditation 01:19:50 First-Time Psychedelic Use, “Entropic Brain Effect”, Neuroplasticity, Cognition 01:30:16 Fibromyalgia & Psychedelic Treatment; MDMA Therapy & “Inner Healer” 01:38:55 Placebo Response & Psychedelic Therapy 01:41:39 LSD & Psychedelic-Therapy, Micro-Dose 01:48:19 Combination Psilocybin-MDMA Therapy 01:56:06 DMT “Rocketship” & Serotonin 2A Receptors; Ibogaine 02:01:04 “Ego Dissolution”, Cocaine vs. Psychedelics; Relapses 02:12:26 Psychedelics & Legal Landscape; Decriminalization 02:17:54 MDMA, Trauma & Clinical Trials; Future Regulatory (FDA) Approval? 02:23:25 Psilocybin & Current Clinical Trials 02:28:41 Mental Health & Psychedelic Treatment, Safeguards, Paradigm Shift 02:34:39 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://hubermanlab.com/disclaimer

In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry. #HubermanLab #Science Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman ROKA: https://roka.com/huberman HVMN: https://hvmn.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Social & Website Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab TikTok - https://www.tiktok.com/@hubermanlab Website - https://hubermanlab.com Newsletter - https://hubermanlab.com/neural-network Articles A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus: https://bit.ly/3oV8zSl Effects of MDMA on sociability and neural response to social threat and social reward: https://bit.ly/3NlOYUC The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity: https://bit.ly/42yMEhl Distinct neural mechanisms for the prosocial and rewarding properties of MDMA: https://bit.ly/3NlNERM Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans: https://bit.ly/42AF6e0 RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy"): https://bit.ly/3J9PTVU Science forced to retract article on “ecstasy”: https://bit.ly/3oRRpVM Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs: https://bit.ly/3P93gcM MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study: https://go.nature.com/3WqI2Zd The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD: https://bit.ly/42wqeNP Books PIHKAL: A Chemical Love Story: https://amzn.to/45ZY80w Trauma: The Invisible Epidemic: https://amzn.to/45VdgfA The Body Keeps the Score: https://amzn.to/3XgH5Dz Other Resources Multidisciplinary Association for Psychedelic Studies (MAPS): https://maps.org Participate in a MAPS trial: https://maps.org/take-action/participate-in-trial Huberman Lab episode on psilocybin: https://bit.ly/43yP80G Huberman Lab episode on psychedelics for mental health: https://bit.ly/3NqC3Rz Huberman Lab episode on dopamine, mindset & drive: https://bit.ly/3IqQzVb Huberman Lab episode on leveraging dopamine: https://bit.ly/3P3dCuD Timestamps 00:00:00 MDMA “Ecstasy” 00:04:37 Sponsors: Helix Sleep, ROKA, HVMN 00:08:18 MDMA History & Synthesis; Legality 00:14:45 MDMA, Methamphetamine (Meth), Dopamine & Serotonin 00:23:30 MDMA vs Psychedelics vs Ketamine 00:26:54 MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma 00:33:36 Sponsor: AG1 00:34:51 Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages 00:45:48 Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD) 00:52:36 Long-Term Effects, Threat Detection & PTSD 00:56:14 MDMA, Social Connection & Empathy; Meth, SSRIs 01:06:10 Sponsor: LMNT 01:07:22 Oxytocin & MDMA 01:16:10 Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl 01:26:36 Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature 01:37:07 Post-MDMA “Crash”, Prolactin & P 5 P 01:43:07 PTSD & Trauma; Talk Therapy, SSRIs 01:54:09 PTSD Treatment: Talk Therapy + MDMA 02:02:46 MDMA & Addiction; Dissociative PTSD & Empathy 02:09:47 Side-Effects?, MDMA Efficacy & Legality 02:15:22 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://hubermanlab.com/disclaimer